γ-Glutamyltransferase in adult rat hepatocyte during proliferation
نویسندگان
چکیده
منابع مشابه
Hepatocyte-specific deletion of hepatocyte nuclear factor-4α in adult mice results in increased hepatocyte proliferation.
Hepatocyte nuclear factor-4α (HNF4α) is known as the master regulator of hepatocyte differentiation. Recent studies indicate that HNF4α may inhibit hepatocyte proliferation via mechanisms that have yet to be identified. Using a HNF4α knockdown mouse model based on delivery of inducible Cre recombinase via an adeno-associated virus 8 viral vector, we investigated the role of HNF4α in the regulat...
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We investigated whether or not beta and alpha adrenergic agonists could affect proliferation of adult rat hepatocytes induced by hepatocyte growth factor (HGF) during the early and late phases of primary culture. Adult rat hepatocytes underwent significant DNA synthesis after culture with 5 ng/ml HGF for 3 h at a low cell density (3.3 x 10(4) cells/cm2). Under these culture conditions, the numb...
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The balance between hepatocyte proliferation and apoptosis is critical for liver homeostasis during liver regeneration. We created a rat liver regeneration model by partial hepatectomy (PH) to investigate the overall mechanism that regulates the proliferation and apoptosis of hepatocytes. The Rat Genome 230 2.0 Array was used to investigate changes in the expression levels of genes associated w...
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Researchers have identified an association between baseline γ-glutamyltransferase (GGT) and prehypertension. However, data from China are limited. A cross-sectional study was performed among 2,205 subjects from Heilongjiang Province in China. Multiple logistic regression analyses revealed a significant association between baseline GGT and prehypertension [1.59, 95% confidence interval (CI), 1.18...
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Cardiovascular epidemiology has recently highlighted a clear link between serum γ-glutamyltransferase (GGT) and risk for stroke, infarction and cardiovascular death, associated with the evolution of atherosclerosis-related conditions, such as coronary artery and cerebrovascular disease. Thus, serum GGT is now recognized as a cardiovascular prognostic marker. However, the reasons for the associa...
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ژورنال
عنوان ژورنال: Experimental & Molecular Medicine
سال: 1996
ISSN: 2092-6413
DOI: 10.1038/emm.1996.3